Gout occurs when there is too much uric acid in the body, which forms crystals that can appear around the joints, leading to painful and swollen joints. Febus 40mg Tablet is a medicine used to treat Gout. This drug helps keep uric acid levels down.
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Febus 40mg Tablet is not known to have an interaction with alcohol. Consult your doctor if you have a habit of drinking alcohol.
Febus 40mg Tablet is generally not recommended for use by pregnant women. Consult your doctor before taking the medicine.
It is not known if the Febus 40mg Tablet can pass into the breastmilk. Seek advice from your doctor if you are a breastfeeding woman.
Febus 40mg Tablet may cause dizziness, sleepiness, blurred vision, or tingling sensation. It is recommended to avoid performing activities like driving and operating machines unless you are sure how this medicine affects you.
Febus 40mg Tablet should be used with caution in patients with or who have had kidney disease. Consult your doctor for advice before taking Febus 40mg Tablet.
Let your doctor know if you have any history of liver disease or hepatic impairment. Your doctor will weigh the benefits and any potential risks before prescribing Febus 40mg Tablet.
Treatment of-
Febus 40mg Tablet works by blocking the action of an enzyme called xanthine oxidase, which is involved in the process of converting hypoxanthine into uric acid (purine metabolism pathway). This type of action reduces high uric acid levels in gout and blood cancer patients undergoing chemotherapy treatment.
Febus 40mg Tablet belongs to the group of medications called xanthine oxidase inhibitors, used for decreasing the symptoms of gouty arthritis.
Febus 40mg Tablet is a selective xanthine oxidase (XO) inhibitor that specifically targets the enzyme xanthine oxidase. By inhibiting this enzyme, Febus 40mg Tablet reduces the production of uric acid, thus lowering serum uric acid levels.
The primary mechanism of action of Febus 40mg Tablet involves blocking xanthine oxidase, which converts hypoxanthine to xanthine and then to uric acid. By inhibiting this conversion, Febus 40mg Tablet helps prevent the accumulation of uric acid crystals in the joints, reducing the frequency and severity of gout attacks.
It's worth noting that Febus 40mg Tablet is a non-purine inhibitor, meaning it does not contain a purine structure like some other gout medications. This characteristic makes Febus 40mg Tablet less likely to interfere with other enzymes involved in purine and pyrimidine production and metabolism, focusing primarily on inhibiting xanthine oxidase.
By specifically targeting xanthine oxidase, Febus 40mg Tablet provides a targeted approach to managing gout and reducing serum uric acid levels.
The dosage and administration details for Febus 40mg Tablet (febuxostat).
The recommended administration instructions for Febus 40mg Tablet are as follows:
The adult dosage for chronic gout is as follows:
Regarding hepatic impairment:
For pediatric patients:
In patients with renal impairment:
It's important to note that these dosage recommendations are general guidelines, and individual dosing may vary based on the patient's specific condition and response to treatment. Always follow the instructions provided by your doctor or healthcare provider for the most accurate and personalized dosage information.
Drug-Drug Interactions:
Drug-Food Interactions:
Drug-Disease Interactions:
Patients being treated with azathioprine, mercaptopurine, or theophylline should exercise caution when using Febus 40mg Tablet (febuxostat) due to potential drug interactions. Febuxostat may increase the levels of these medications in the body, leading to an increased risk of side effects. It is important to monitor the patient closely for any signs of toxicity or adverse reactions when using Febus 40mg Tablet concurrent with azathioprine, mercaptopurine, or theophylline.
In such cases, it is advisable for the patient's healthcare provider to adjust the dosage of these medications as necessary and closely monitor their response to treatment. The healthcare provider will consider the potential benefits and risks of co-administering these drugs and make an informed decision based on the individual patient's condition. Regular monitoring of blood levels and clinical evaluation are crucial to ensure the safe and effective use of these medications together.
It is recommended to inform your doctor about all the medications you are taking, including prescription, over-the-counter, and herbal supplements, to ensure appropriate management and minimize the risk of drug interactions. Your healthcare provider is in the best position to provide personalized advice and guidance regarding the simultaneous use of Febus 40mg Tablet with azathioprine, mercaptopurine, or theophylline.
Febuxostat is classified as pregnancy category C by the US Food and Drug Administration (FDA), which means that there are no sufficient and well-controlled studies on pregnant women. The use of Febuxostat during pregnancy should only be considered if the potential benefits to the mother outweigh the potential risks to the fetus.
Regarding breastfeeding, it is not known whether Febuxostat is excreted in human milk. Therefore, caution should be exercised when using Febuxostat in breastfeeding mothers. The potential risks and benefits should be carefully evaluated, and it is advisable to consult with a healthcare professional for personalized advice in such situations.
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.
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